Mikroalbuminúria
Mikroalbuminúria ako marker
Chronického ochorenia obličiek
(diabetická nefropatia, vaskulárna nefroskleróza, GN...)
Nezávislý marker endotelovej dysfunkcie a KV ochorenia
Včasný prognostický KV faktor
Albuminúria
UAE = urinary albumin excretion
24-hodinový zber moča
UAE mg/d (N < 30 mg/d) resp.μg/min (N < 20 μg/min )
UAC mg/l (N < 20 mg/l)
ACR (albumin/creatinin ratio)
N < 2,5 mg/mmol M, < 3,5 mg/mmol Ž
N < 30 mg/g
výpočet ACR podľa noriem LABMED
U-albumín (mg/l) U-albumín (mg/l)
U-kreatinín (g/l ) U-kreatinín (mmol/l) / 8,84
Albuminúria a mortalita
Pacienti s makroalbuminúriou a zníženou GF 15-30 ml/s majú 8 vyššiu KV mortalitu ako referenčná skupina (Ref.) s normálnou GF a normoalbuminúriou po zohľadnení známych KV rizikových faktorov.
1. van der Velde M, Matsushita K, Coresh J, et al. Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts. Kidney Int. 2011. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21307840 .
2. Gansevoort RT, Matsushita K, van der Velde M, et al. Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes in both general and high-risk populations. A collaborative meta-analysis of general and high-risk population cohorts. Kidney Int. 2011. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21289597 .
3. Matsushita K, van der Velde M, Astor BC, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375(9731):2073-2081.
